Car misfires 5% of the time
If you have a scan tool (guessing you do, since you mentioned monitoring the O2's), I'd take a look at fuel trims and misfire counters, preferably while driving so you can save the data. If it's been a while since the plugs & wires were done, that's also a cheap fix to throw at it and see what happens.
Ignition coils 99% of the time are either good or bad, they don't usually come and go.
A funny plug or plug wire though, I have seen many times come and go.
There are many things that can cause an occasional misfire like build up on valves, old injectors etc so that's why I said some of it isn't necessarily a concern.
Plugs and wires should last longer but things happen and sometimes you get a crappy plug. Happened to me this year with my truck. I put in brand new NGK plugs and right after I had a misfire at heavy throttle on cylinder 5. Had to swap that plug with another new one and went ahead and did new plug wires just because.





