Mid to hi 10's with the 348 block is definitely do-able. But, I didn't see what kind/size heads & cam come with the 348. Lift isn't everything....duration is every bit as important, if not more so. Yeah, a .600 lift opens the valves a long way, but for how long? Duration has a huge impact on intake/exhaust flow. What about the intake/throttle body? The LS6 intake is about as good as it gets, as far as OEM intakes go, but if you're going with a forged engine, high-flowing heads (both the 205 & 225 AFR Mongoose heads flow like a mother), and a cam with some rumpety-rump, you may want to consider a FAST 90mm intake/throttle body.
Will you be using your OEM PCM? If so, get a GOOD tune, or all of those parts won't perform up to their full potential. And if you're going to be laying down that kind of power, and you plan on up-grading your A4, it's going to cost you. There are many sources for good, hi-quality 4L60e transmissions that'll take 600+ HP, but from what I've seen, plan on spending between 2 to 3 large for a good one. If you cheap out on a 4L60e in a hi-performance application, it isn't going to last very long.