What are the best heads for a ls6?
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Remember, with the MS3 cam you WILL have to flycut the pistons if going with the AFR's (same goes for the Darts). The ETP heads (and Trickflow I believe) have more PV clearance than stock so you will NOT have to flycut the pistons. ETP has a head with a 215 intake runner that I think would rock the **** out of the MS3 if you did not want to flycut.
That being said, if you are going to spend money on one of the best sets of heads for the LSx market, flycut your pistons yourself or pay someone to do it and go with the AFR 205s. There is a guy on here, allngn_c5, who put down 473 rwhp 431 rwtq with AFR 205s, a similar sized cam (g5x3) and a fast 90/90 setup with all the other bolt ons. I'm not saying your numbers would necessarily be that high, but you could definately get up there. I don't think I've seen an MS3 with a set of 205s yet
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Here's the rub, only the ET 215 and PRC 243 heads (with stock valve sizes) even have a prayer of giving you enough P to V clearance with a cam of that duration. At 59cc, I'm afraid that even those heads may not give you enough. Consider flycutting.
In a nutshell, a head with a compression advantage will often make more power than a head with a flow advantage. I would take a PRC 243 head at 59cc over an AFR 205 head at 66cc. Compression has the advantage in this case. If money is no object, then certainly you'll have the resources to flycut your pistons and run the best flowing head at the smaller combustion chamber size.
If you had no P to V clearance isssues, I would go with the head that had the best flow in the .300-.500" range. Most flow comparisons I've seen show the ET heads having the biggest advantage in this area.

2013 Corvette Grand Sport A6 LME forged 416, Greg Good ported TFS 255 LS3 heads, 222/242 .629"/.604" 121LSA Pat G blower cam, ARH 1 7/8" headers, ESC Novi 1500 Supercharger w/8 rib direct drive conversion, 747rwhp/709rwtq on 93 octane, 801rwhp/735rwtq on race fuel, 10.1 @ 147.25mph 1/4 mile, 174.7mph Half Mile.
2016 Corvette Z51 M7 Magnuson Heartbeat 2300 supercharger, TSP LT headers, Pat G tuned, 667rwhp, 662rwtq, 191mph TX Mile.
2009.5 Pontiac G8 GT 6.0L, A6, AFR 230v2 heads. 506rwhp/442rwtq. 11.413 @ 121.29mph 1/4 mile, 168.7mph TX Mile
2000 Pewter Ram Air Trans Am M6 heads/cam 508 rwhp/445 rwtq SAE, 183.092 TX Mile
2022 Cadillac Escalade 6.2L A10 S&B CAI, Corsa catback.
2023 Corvette 3LT Z51 soon to be modified.
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