If I have a 2009 6.0 and PCM from a 2500 pickup, can the PCM be reprogrammed to run an earlier OD transmission like a 4L60E or 4L65E. Newby, Thanks, Chris

 

No probably not. It cant control any transmission as there are no instruction set or outputs from the ecm that can control anything transmission related.
There are however, lots of aftermarket transmission controllers that will work.