Does weather affect VE tuning?

A buddy and I started getting my VE dialed in last night, but we didn't get completely finished. So, my basic question is whether or not the weather from one day to another would have a substantial impact on the changes we previously made or not.
A side question is that I'm curious if you guys have had to drop the VE in the lower RPM band much with your VE tuning? I'm finding that I need to drop it down low, but up in the midrange it evens out, and I'm assuming once we tune the top end it will be lean?
I won't comment on what all changed because I think my car is weird.
I was just logging in to post another question related to it in fact. 
