70RallySport

If I replace my instrument cluster with one from another truck do I have to have my Vin# programmed into it?

9000th01ss

iTrader: (10)

No, it'll work like the original.
Assuming by truck you mean one related to this site.

SSpdDmon

iTrader: (10)

The cluster will swap, but it will most likely contain the mileage from the donor car - not yours. You need to have your mileage programed in by an authorized vendor. I used www.specmo.com.

01WS6/tamu

iTrader: (37)

99-02 you will be fine. If you are an 03 and up you may run into goof things with the dic on the cluster if it is not programmed for certain options the truck is equipped with. However if the truck is a match between the two you will be fine.