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It SHOULD clear stock valeve size and MLS gasket and no milling...
haha SHOULD is the key word here......i know of quite a few cam only ls1s running a MS4 but i personaly would feel alot better if it were my car to have the PTV clearance checked. just my .02
A buddy of mine is running this exact combo (stock, unmilled 243s), but with a cam that big, I would still check PTV since the heads will be off anyway. It'll take 10 minutes.