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I've seen cars run a 200 shot with too hot of a plug on a bad tune up and be fine. They only did it a time or two, though. And they didn't really gain much.
The tune up needs to be spot on to make it safe and to be worth doing.
yes it can if the fuel system can support it and its has different plugs
Also to add to what he said you need to make sure you have the correct amount of timing pulled and the tune up has to damn near be spot on or it's gonna go bad real quick.