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I don't want too much power. I'll be happy with 325-350 rwhp.
With that hp goal, yes, you will need at least a cam swap. Since you're there, springs/rockers too. A 52mm TB is more than adequate. Then you'll definitely need a tune. Good luck.
Don't waste your money on a larger throttle body. The stock one is good for 500 HP. The LT4 valve springs and retainers are a good upgrade for a stock cam LT1.